Consumption of a Mango Fruit Powder Protects Mice from High-Fat Induced Insulin Resistance and Hepatic Fat Accumulation
Related Experiment Video
Updated: Mar 1, 2026
Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
Published on: September 9, 2021
Agustín G Sabater1, Joan Ribot1, Teresa Priego1,2
1Nutrigenomic and Obesity research group, Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Palma de Mallorca, Spain.
Background/Aims:
The aim of this study was to gain more insight into the beneficial effects of mango fruit powder on the early metabolic adverse effects of a high-fat diet.
Methods:
The progressive dose-response effects of mango fruit powder on body composition, circulating parameters, and the expression of genes related to fatty acid oxidation and insulin sensitivity in key tissues were studied in mice fed a moderate (45%) high-fat diet.
Results:
Findings suggest that mango fruit powder exerts physiological protective effects in the initial steps of insulin resistance and hepatic lipid accumulation induced by a high-fat diet in mice. Moreover, AMPK and SIRT1 appear as key regulators of the observed improvement in fatty acid oxidation capacity, as well as of the improved insulin sensitivity and the increased glucose uptake and metabolism through the glycolytic pathway capacity in liver and skeletal muscle.
Conclusion:
In summary, this study provides evidence that the functional food ingredient (CarelessTM) from mango fruit prevents early metabolic alterations caused by a high-fat diet in the initial stages of the metabolic syndrome.
Insights
Mango fruit powder helps prevent early metabolic issues like insulin resistance and fat buildup caused by high-fat diets. It supports fatty acid oxidation and glucose metabolism in key tissues.
Area of Science:
- Nutritional Science
- Metabolic Health
- Dietary Interventions
Background:
- High-fat diets induce early metabolic dysfunction, including insulin resistance and hepatic lipid accumulation.
- Understanding protective dietary components is crucial for managing metabolic syndrome.
- Mango fruit powder is explored for its potential health benefits.
Purpose of the Study:
- To investigate the beneficial effects of mango fruit powder on early metabolic adverse effects of a high-fat diet.
- To elucidate the mechanisms underlying these protective effects.
Main Methods:
- A dose-response study was conducted in mice fed a moderate high-fat diet.
- Evaluated effects on body composition, circulating parameters, and gene expression.
- Focused on genes related to fatty acid oxidation and insulin sensitivity in liver and skeletal muscle.
Main Results:
- Mango fruit powder demonstrated protective effects against early insulin resistance and hepatic lipid accumulation.
- AMPK and SIRT1 were identified as key regulators of improved fatty acid oxidation.
- Enhanced insulin sensitivity and glucose uptake/metabolism were observed in liver and skeletal muscle.
Conclusions:
- Mango fruit powder (CarelessTM) prevents early metabolic alterations associated with high-fat diets.
- This functional ingredient shows promise in mitigating initial stages of metabolic syndrome.
- The study highlights mango's role in maintaining metabolic health.
