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Downregulation of lncRNA TUBA4B is Associated with Poor Prognosis for Epithelial Ovarian Cancer

Fang-Fang Zhu1, Fei-Yun Zheng1, Hai-Ou Wang2

  • 1Department of Gynaecology, the First Affiliated Hospital of Wenzhou Medical University, 1 Fuxue Lane, Lucheng District, Wenzhou, Zhejiang, 325000, People's Republic of China.

Pathology Oncology Research : POR
|June 5, 2017
PubMed

Insights

Lower levels of long non-coding RNA TUBA4B (lncRNA TUBA4B) are linked to poorer outcomes in epithelial ovarian cancer. Restoring lncRNA TUBA4B expression inhibits cancer cell growth, suggesting its therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) play a role in epithelial ovarian cancer (EOC) development.
  • LncRNA TUBA4B is implicated in non-small cell lung cancer, but its role in EOC is unclear.

Purpose of the Study:

  • Investigate lncRNA TUBA4B expression in EOC tissues.
  • Determine the prognostic value of lncRNA TUBA4B in EOC.
  • Explore the functional role of lncRNA TUBA4B in EOC cells.

Main Methods:

  • Quantitative analysis of lncRNA TUBA4B expression in EOC tissues and adjacent normal tissues.
  • Correlation analysis between lncRNA TUBA4B levels and clinical parameters (pathological grade, FIGO stage, lymph node metastasis, CA125).
  • In vitro experiments involving enforced expression of lncRNA TUBA4B in SKOV3 cells to assess effects on proliferation, migration, and signaling pathways (ERK, Akt).

Main Results:

  • LncRNA TUBA4B expression was significantly decreased in EOC tissues compared to normal tissues.
  • Low lncRNA TUBA4B levels correlated with advanced pathological grade, FIGO stage, lymph node metastasis, and elevated serum CA125.
  • Enforced lncRNA TUBA4B expression reduced SKOV3 cell proliferation and attenuated ERK and Akt signaling.

Conclusions:

  • Reduced lncRNA TUBA4B expression is a potential independent prognostic biomarker for overall survival in epithelial ovarian cancer.
  • Overexpression of lncRNA TUBA4B inhibits ovarian cancer cell proliferation.
  • LncRNA TUBA4B represents a potential therapeutic target for ovarian cancer.
Keywords:
Ovarian cancerOverall survivalProliferationlncRNA

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