Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

774
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
774
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

6.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.1K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.7K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

710
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
710
What are Lipids?01:38

What are Lipids?

223.2K
Overview
223.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co-occurrence of nephrocalcinosis and nephrolithiasis in feline kidneys.

Journal of veterinary internal medicine·2026
Same author

Differential gene expression analysis in French bulldog high grade oligodendroglioma: breed-associated differences in tumor and tumor microenvironment gene expression.

Companion animal health and genetics·2026
Same author

Serum and urine metabolomic profiling in Miniature Schnauzer dogs with and without calcium oxalate urolithiasis.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Feline plasma cell pododermatitis with concurrent glomerular disease: a case series of 25 cats.

Journal of feline medicine and surgery·2026
Same author

Outcomes of medical dissolution for suspected struvite uroliths in dogs using a therapeutic multipurpose urinary diet and antimicrobial therapy.

Journal of veterinary internal medicine·2026
Same author

A novel missense variant in the calcium-sensing receptor gene in a dog with hypercalcemia.

Journal of veterinary internal medicine·2026

Related Experiment Video

Updated: Mar 1, 2026

Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells
08:37

Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells

Published on: March 10, 2023

3.5K

Glomerular Lipidosis in Dogs.

Rebecca A Kohnken1, Hayley Amerman1, Cathy A Brown2

  • 11 Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH.

Veterinary Pathology
|June 6, 2017
PubMed
Summary
This summary is machine-generated.

Glomerular lipidosis (GL) in dogs is not just an incidental finding but is associated with kidney dysfunction. This condition often co-occurs with other renal lesions and clinical abnormalities, indicating significant kidney injury.

Keywords:
glomerulushypertensionkidneylipidproteinuriarenal

More Related Videos

Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
07:12

Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment

Published on: June 2, 2023

8.7K
Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
07:43

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

11.0K

Related Experiment Videos

Last Updated: Mar 1, 2026

Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells
08:37

Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells

Published on: March 10, 2023

3.5K
Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
07:12

Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment

Published on: June 2, 2023

8.7K
Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
07:43

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

11.0K

Area of Science:

  • Veterinary Pathology
  • Canine Nephrology
  • Renal Histopathology

Background:

  • Glomerular lipidosis (GL) characterized by lipid-laden foam cells in glomerular capillaries was previously considered incidental.
  • Increased awareness of canine chronic kidney disease (CKD) highlights the importance of proteinuria and hypertension in renal assessment.
  • The International Renal Interest Society staging system emphasizes comprehensive evaluation of renal function.

Purpose of the Study:

  • To investigate clinical abnormalities associated with glomerular lipidosis (GL) in dogs.
  • To identify concurrent renal lesions in dogs diagnosed with GL.
  • To determine if GL represents a distinct histologic phenotype of glomerular injury.

Main Methods:

  • Analysis of renal biopsies from 46 dogs with GL evaluated by the International Veterinary Renal Pathology Service.
  • Review of clinicopathologic data, including proteinuria, hypertension, azotemia, and hypoalbuminemia.
  • Correlation of GL severity and percentage of affected glomeruli with concurrent diagnoses and age.

Main Results:

  • GL was the sole diagnosis in 11% of cases, all of which were proteinuric and showed other clinicopathologic abnormalities.
  • Common concurrent glomerular lesions included focal segmental glomerulosclerosis (35%), juvenile nephropathy (17%), and amyloidosis (11%).
  • Dogs with severe GL were significantly younger than those with mild GL (P < .001); higher percentages of affected glomeruli were seen in GL alone or with juvenile nephropathy.

Conclusions:

  • Glomerular lipidosis (GL) is associated with clinical renal dysfunction and should not be considered an incidental finding.
  • GL represents a significant histologic phenotype of glomerular injury in dogs.
  • GL may be linked to juvenile nephropathies, suggesting a potential role in inherited or developmental kidney diseases.