Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chromatin Immunoprecipitation- ChIP02:36

Chromatin Immunoprecipitation- ChIP

12.7K
Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
12.7K
Heterochromatin02:38

Heterochromatin

18.9K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
18.9K
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

7.5K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of alone & combined application of benzylaminopurine and gibberellic acid on in-vitro germination and growth rate of broccoli.

BMC plant biology·2026
Same author

Harnessing the therapeutic potential of chitosan/PVA/AEAPTS-modified bentonite clay hydrogels for enhanced angiogenesis and rapid wound healing.

International journal of biological macromolecules·2026
Same author

Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability.

Computational and structural biotechnology journal·2025
Same author

16S rRNA gene sequencing reveals bacterial diversity in Khewra Salt Mine walls.

Access microbiology·2025
Same author

Coordination Polymer Carrying Antimicrobial Peptide for Enhanced Anti-Infective Therapy.

Chembiochem : a European journal of chemical biology·2025
Same author

Enhancements of the first and second hyperpolarizability of a GMP coordination polymer: crystal structure and computational studies.

Dalton transactions (Cambridge, England : 2003)·2025

Related Experiment Video

Updated: Mar 1, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

412.0K

ChromBiSim: Interactive chromatin biclustering using a simple approach.

Nighat Noureen1, Hafiz Muhammad Zohaib1, Muhammad Abdul Qadir2

  • 1Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.

Genomics
|June 6, 2017
PubMed
Summary
This summary is machine-generated.

ChromBiSim is a new tool that finds local patterns in histone modifications. It helps decode combinations of these modifications across multiple cell types for disease research.

Keywords:
BiclustersBinarization approachGenome wide histone marksHistone code hypothesisLocal patterns

More Related Videos

Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

88.7K
A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.7K

Related Experiment Videos

Last Updated: Mar 1, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

412.0K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

88.7K
A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.7K

Area of Science:

  • Genomics
  • Epigenetics
  • Computational Biology

Background:

  • Histone modifications are crucial epigenetic marks that define genomic regions.
  • Current methods often overlook local combinatorial patterns of these modifications.
  • Understanding these local patterns is key to deciphering gene regulation.

Purpose of the Study:

  • To introduce ChromBiSim, an interactive tool for mining combinatorial patterns of histone modifications.
  • To enable the analysis of local epigenomic patterns across multiple cell types.
  • To facilitate the identification of variations between normal and diseased cells.

Main Methods:

  • ChromBiSim employs biclustering algorithms to extract subsets of modifications and their genomic locations.
  • The tool provides a user interface for interactive exploration and visualization.
  • Results are presented as charts and heat maps, with options for file export.

Main Results:

  • ChromBiSim successfully identified 803 combinatorial patterns across multiple cell types.
  • The tool efficiently extracts biclusters and their corresponding genomic locations.
  • Demonstrated potential for highlighting differences between diseased and normal cell types.

Conclusions:

  • ChromBiSim is the first user-friendly, multi-cell type tool for analyzing histone modification combinations.
  • It effectively reveals local epigenomic patterns and their interplay.
  • The tool has significant implications for comparative epigenomics and disease research.