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Updated: Mar 1, 2026
Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
Published on: March 19, 2020
Dinuclear cobalt(II) complexes with double phosphate ester bridges and tetradentate ligands having anisole or
S S Anjana1, Babu Varghese2, Edamana Prasad1
1Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India.
Abstract:
Phosphate esters provide a rigid and stable polymeric backbone in nucleic acids. Metal complexes with phosphate ester groups have been synthesized as structural and spectroscopic models of phosphate-containing enzymes. Dinucleating ligands are used extensively to synthesize model complexes since they provide the support required to stabilize such complexes. The crystal structures of two dinuclear CoII complexes, namely bis(μ-diphenyl phosphato-κ2O:O')bis({2-methoxy-N,N-bis[(pyridin-2-yl)methyl]aniline-κ4N,N',N'',O}cobalt(II)) bis(perchlorate), [Co(C12H10O4P)2(C19H19N3O)2](ClO4)2, and bis(μ-diphenyl phosphato-κ2O:O')bis({N,N-bis[(pyridin-2-yl)methyl]quinolin-8-amine-κ4N,N',N'',O}cobalt(II)) bis(perchlorate), [Co(C12H10O4P)2(C21H18N4)2](ClO4)2, with tetradentate 2-methoxy-N,N-bis[(pyridin-2-yl)methyl]aniline (L1) and N,N-bis[(pyridin-2-yl)methyl]quinolin-8-amine (L2) ligands are reported. The complexes have similar structures, with distorted octahedral geometries around the metal centres. Both are centrosymmetric (Z' = 0.5), with the CoII centres doubly bridged by diphenyl phosphate ester groups. A number of aromatic-aromatic interactions are present and differ between the two complexes as the anisole group in L1 is replaced by a quinoline group in L2. A detailed study of these interactions is presented.
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