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Updated: Mar 1, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
A case of primary amyloidosis with spontaneous hepatic rupture
1Department of Internal Medicine, Koseiren Namerikawa Hospital.
Abstract:
A 79-year-old man was diagnosed to have primary amyloid light-chain (AL) amyloidosis with associated liver damage and prominent hepatomegaly. He was followed up without any treatment. One year after the diagnosis, he was taken to the hospital with a sudden onset of features of shock. Computed tomography revealed hepatic rupture, and he was treated by emergent transcutaneous arterial embolization. However, the procedure was unable to save his life. AL amyloidosis with prominent hepatomegaly is considered to be a risk factor for spontaneous liver rupture and intra-abdominal hemorrhage.
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