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Updated: Mar 1, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Oridonin inhibits breast cancer growth and metastasis through blocking the Notch signaling

Shixin Xia1, Xiulan Zhang2, Caihong Li3

  • 1Pharmaceutical Preparation Section, Weifang People's Hospital, Weifang 261500, China.

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
|June 6, 2017
PubMed
Abstract

Insights

Oridonin, a compound from Rabdosia rubescens, inhibits breast cancer growth and metastasis by reducing Notch signaling and increasing apoptosis. This natural product shows promise for breast cancer treatment.

Area of Science:

  • Pharmacology
  • Oncology
  • Molecular Biology

Background:

  • Oridonin, a diterpenoid from Rabdosia rubescens, exhibits significant anticancer properties.
  • Breast cancer remains a leading cause of cancer-related mortality worldwide.
  • Investigating novel therapeutic agents for breast cancer is crucial.

Purpose of the Study:

  • To investigate the inhibitory effects of oridonin on human breast cancer cell growth and metastasis.
  • To elucidate the underlying molecular mechanisms of oridonin's action.
  • To evaluate oridonin's efficacy in preclinical models.

Main Methods:

  • In vitro studies using MTT assays, transwell migration, and invasion assays.
  • In vivo efficacy assessment in xenografted nude mouse models.
  • Western blot analysis to detect Notch receptor (Notch 1-4) expression.

Main Results:

  • Oridonin demonstrated significant inhibition of human breast cancer cell proliferation, migration, and invasion both in vitro and in vivo.
  • Oridonin treatment led to increased apoptosis in breast cancer cells.
  • A notable decrease in the expression of Notch 1-4 proteins was observed following oridonin treatment.

Conclusions:

  • Oridonin exhibits potent anti-breast cancer activity.
  • The anticancer effects of oridonin are associated with the inhibition of the Notch signaling pathway.
  • Oridonin-induced apoptosis contributes to its therapeutic potential in breast cancer.
Keywords:
Breast cancerCell apoptosisNotch signaling pathwayOridonin

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