Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.3K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.3K
Time and frequency -Domain Interpretation of Phase-lag Control01:21

Time and frequency -Domain Interpretation of Phase-lag Control

429
Phase-lag controllers are widely used in control systems to improve stability and reduce steady-state errors. A dimmer switch controlling the brightness of a light bulb serves as a practical example of phase-lag control, gradually adjusting the bulb's brightness. Mathematically, phase-lag control or low-pass filtering is represented when the factor 'a' is less than 1.
Phase-lag controllers do not place a pole at zero, but instead influence the steady-state error by amplifying any...
429
Residuals and Least-Squares Property01:11

Residuals and Least-Squares Property

9.7K
The vertical distance between the actual value of y and the estimated value of y. In other words, it measures the vertical distance between the actual data point and the predicted point on the line
If the observed data point lies above the line, the residual is positive, and the line underestimates the actual data value for y. If the observed data point lies below the line, the residual is negative, and the line overestimates the actual data value for y.
The process of fitting the best-fit...
9.7K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

374
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
374
Empirical Method to Interpret Standard Deviation01:09

Empirical Method to Interpret Standard Deviation

10.4K
The empirical rule, also known as the three-sigma rule, allows a statistician to interpret the standard deviation in a normally distributed dataset. The rule states that 68% of the data lies within one standard deviation from the mean, 95% lies within two standard deviations from the mean, and 99.7% lies within three standard deviations from the mean. Additionally, this rule is also called the 68-95-99.7 rule.
This rule is used widely in statistics to calculate the proportion of data values...
10.4K
Noncompartmental Analysis: Mean Residence Time01:05

Noncompartmental Analysis: Mean Residence Time

672
According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
672

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

More extreme Indian monsoon rainfall in El Niño summers.

Science (New York, N.Y.)·2025
Same authorSame journal

Tuning Earth System Models Without Integrating to Statistical Equilibrium.

Journal of advances in modeling earth systems·2024
Same author

A mutual information criterion with applications to canonical correlation analysis and graphical models.

Stat (International Statistical Institute)·2021
Same author

Standard assessments of climate forecast skill can be misleading.

Nature communications·2021
Same author

Monthly ENSO Forecast Skill and Lagged Ensemble Size.

Journal of advances in modeling earth systems·2018
Same author

The Weighted-Average Lagged Ensemble.

Journal of advances in modeling earth systems·2018
Same journal

A New Aerosol Dry Deposition Model for Air Quality and Climate Modeling.

Journal of advances in modeling earth systems·2025
Same journal

BioRT-HBV 1.0: A Biogeochemical Reactive Transport Model at the Watershed Scale.

Journal of advances in modeling earth systems·2024
Same journal

Accurate and Efficient Numerical Simulation of Land Models Using SUMMA With SUNDIALS.

Journal of advances in modeling earth systems·2024
Same journal

Reconstructing the Tropical Pacific Upper Ocean Using Online Data Assimilation With a Deep Learning Model.

Journal of advances in modeling earth systems·2024
Same journal

Estimating Ocean Heat Uptake Using Boundary Green's Functions: A Perfect-Model Test of the Method.

Journal of advances in modeling earth systems·2023
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
06:44

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Published on: September 23, 2025

637

A new method for determining the optimal lagged ensemble.

L Trenary1,2, T DelSole1,2, M K Tippett3,4

  • 1George Mason University Fairfax Virginia USA.

Journal of Advances in Modeling Earth Systems
|June 6, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a method to optimize lagged ensembles for minimizing forecast errors. For Madden-Julian Oscillation (MJO) forecasts, larger ensembles or more frequent initializations beyond a certain point offer minimal skill improvement.

Keywords:
CFSv2methodologysubseasonal forecasting

More Related Videos

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

6.1K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.2K

Related Experiment Videos

Last Updated: Mar 1, 2026

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
06:44

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Published on: September 23, 2025

637
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

6.1K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.2K

Area of Science:

  • Atmospheric Science
  • Climate Modeling
  • Data Assimilation

Background:

  • Lagged ensemble forecasting is crucial for improving weather and climate predictions.
  • Accurate estimation of forecast errors is essential for ensemble optimization.
  • The Madden-Julian Oscillation (MJO) presents a significant challenge for subseasonal to seasonal prediction.

Purpose of the Study:

  • To develop a general methodology for determining optimal lagged ensemble configurations.
  • To minimize the mean square forecast error (MSE) for ensemble forecasts.
  • To apply and validate this methodology using the Climate Forecast System version 2 (CFSv2) for MJO prediction.

Main Methods:

  • Developed a method based on the cross-lead error covariance matrix to determine optimal ensemble size and initialization frequency.
  • Estimated the cross-lead error covariance matrix from hindcast data and parameterized it using analytic functions.
  • Applied the methodology to CFSv2 MJO forecasts and analyzed forecast skill for various ensemble parameters.
  • Investigated the impact of initialization frequency on capturing error covariance structures.
  • Demonstrated optimal weighting of ensemble members to reduce forecast error.

Main Results:

  • The MSE of a lagged ensemble depends solely on the cross-lead error covariance matrix.
  • Forecast skill for MJO improves little with ensemble sizes larger than 5 days or initializations more frequent than 4 times per day for leads > 1 week.
  • Infrequent initializations can lead to the loss of critical error covariance matrix structures.
  • Optimal weighting of lagged ensemble members can significantly reduce forecast error at longer lead times (≥10 days).

Conclusions:

  • The proposed methodology provides a general framework for optimizing lagged ensemble forecasts.
  • The findings offer practical guidance for configuring ensemble forecasts for systems like CFSv2, particularly for MJO prediction.
  • The technique is adaptable to other numerical weather prediction and climate forecast systems.