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Updated: Mar 1, 2026

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Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
Published on: February 9, 2012
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Visualising the membrane viscosity of porcine eye lens cells using molecular rotors
Peter S Sherin1,2, Ismael López-Duarte3, Michael R Dent3
1International Tomography Center SB RAS , Institutskaya Street 3A , 630090 , Novosibirsk , Russia .
Chemical Science
|June 6, 2017
Abstract:
The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive 'molecular rotors' to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation.

