Related Experiment Video

Updated: Mar 1, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Kinase modulation of androgen receptor signaling: implications for prostate cancer

Kalpit Shah1, Neil A Bradbury1

  • 1Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine & Sciences, North Chicago, IL, 60064, USA.

Cancer Cell & Microenvironment
|June 6, 2017
PubMed

Insights

Phosphorylation of androgen receptors is crucial in prostate cancer progression. Understanding these phosphorylated forms may lead to new therapeutic targets for prostate and castrate-resistant prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Androgens and androgen receptors are key drivers in prostate cancer development and progression.
  • Androgen receptor activity is modulated by post-translational modifications, including phosphorylation.
  • Phosphorylation significantly impacts androgen receptor function and cancer cell biology.

Purpose of the Study:

  • To review recently identified protein kinases that phosphorylate the androgen receptor.
  • To focus on the functional significance of phosphorylated androgen receptor species in prostate cancer.
  • To explore therapeutic implications for prostate cancer and castrate-resistant prostate cancer.

Main Methods:

  • Literature review of recent studies on androgen receptor phosphorylation.
  • Analysis of protein kinases involved in androgen receptor phosphorylation.
  • Synthesis of functional roles of phosphorylated androgen receptor species.

Main Results:

  • Several protein kinases have been identified as phosphorylating the androgen receptor.
  • Phosphorylation influences androgen receptor localization, stability, and transcriptional activity.
  • Altered androgen receptor phosphorylation is linked to cancer progression.

Conclusions:

  • Understanding phosphorylated androgen receptor species is vital for targeted therapies.
  • Targeting specific phosphorylation pathways may offer new treatment strategies for prostate cancer.
  • Further research into androgen receptor kinases is warranted for therapeutic development.
Keywords:
Androgen ReceptorCastrate Resistant Prostate CancerKinasesLMTK2LynMAPKProstate CancerSignaling

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