A Case with late onset of ambiguous genitalia
Soraya Saleh Gargari1, Faezeh Azizi2, Nasrin Saleh3
1Feto-Maternal Unit, Mahdieh Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran.
Background:
Ambiguous genitalia is an uncommon situation that happens between 1 and 2 per every 1000 live births and falls under the umbrella diagnosis of disorders of sexual development.
Case:
In this article, we report a case of male pseudohermaphroditism with ambiguous genitalia. The proband was a 12 yr old girl without any uterus or ovarian tissues. Karyotype of the case is 46, XY. Genes involved in sexual differentiation such as AR, SRD5A2, LH, LHR, FSH, 17 B HSD and SRY genes were sequenced in both directions. No mutations were found in these genes either.
Conclusion:
It seems advisable to be cautious in similar cases, and revise protocol for tracing the genes involved in the patients.
Related Concept Videos
Development of the Sexual Organs in the Embryo and Fetus
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
External Female Genitals
Psychosexual Stages of Personality: Genital
Psychosexual Stages of Personality: Phallic
Psychosexual Stages of Personality: Latency
The latency period is not...
Psychosexual Theory of Development
The Five Stages of Psychosexual Development
Freud's psychosexual...


