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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

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Combating multidrug-resistant Plasmodium falciparum malaria.

Aung Myint Thu¹, Aung Pyae Phyo^1,2, Jordi Landier¹

¹Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.

The FEBS Journal

|June 6, 2017

Summary

Plasmodium falciparum malaria is developing resistance to antimalarial drugs. This article outlines context-specific strategies to prevent and combat drug resistance, aiming to preserve malaria control gains.

Keywords:

Plasmodium falciparum antimalarial drug resistance artemisinin resistance malaria elimination multidrug resistance malaria

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Area of Science:

Malariology
Infectious Diseases
Drug Resistance

Background:

Plasmodium falciparum has evolved resistance to multiple antimalarial drugs over 50 years.
Emerging resistance to artemisinin derivatives threatens current malaria control efforts.
Drug resistance develops progressively, impacting treatment efficacy and geographic range.

Purpose of the Study:

To present context-specific strategies for combating drug-resistant Plasmodium falciparum malaria.
To outline approaches for preventing resistance emergence and managing increasing resistance.
To discuss interventions for scenarios of widespread and complete antimalarial drug failure.

Main Methods:

Review of historical patterns of antimalarial drug resistance.
Development of context-specific intervention frameworks based on resistance prevalence.
Integration of vector control, diagnostics, combination therapies, and personal protection.

Main Results:

Strategies vary depending on the stage of drug resistance, from sensitive parasites to complete drug failure.
Emphasis on prevention of resistance, transmission disruption, and novel combination therapies.
Elimination and personal protection are key in later stages of resistance.

Conclusions:

A multipronged, holistic approach is essential for combating drug-resistant malaria.
Proactive strategies are needed to stay ahead of evolving Plasmodium falciparum resistance.
Sustained malaria control requires adaptive and comprehensive resistance management plans.