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Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense
Mohammad Nur-E-Alam, Muhammad Yousaf, Sarfaraz Ahmed
1Institute of Biological, Environmental & Rural Sciences (IBERS), Aberystwyth University , Aberystwyth SY23 3DA, United Kingdom.
Journal of Natural Products
|June 6, 2017
Summary
Medicinal plant Teucrium yemense yielded six new neoclerodane diterpenoids. These compounds, including fatimanol A-E and fatimanone, expand knowledge of secondary metabolites in the Teucrium genus.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Medicinal Plant Research
Background:
- Teucrium yemense (Reehal Fatima) is a medicinal plant native to Saudi Arabia and Yemen.
- The Teucrium genus and Lamiaceae family are known for anthelmintic and antimicrobial properties.
Purpose of the Study:
- To isolate and characterize secondary metabolites from Teucrium yemense.
- To investigate the structural diversity of neoclerodane diterpenoids within the Teucrium genus.
Main Methods:
- Phytochemical investigation of aerial parts of T. yemense.
- Structure elucidation using 2D NMR and Mass Spectrometry (MS).
- X-ray crystallographic analysis for structural confirmation.
Main Results:
- Six new neoclerodane diterpenoids (fatimanol A-E and fatimanone) were identified.
- The known compound teulepicephin was also isolated.
- The structure of fatimanol D was confirmed via X-ray crystallography.
Conclusions:
- The study expands the known repertoire of secondary metabolites in the Teucrium genus.
- New diterpenoids were discovered, contributing to natural product chemistry.
- Further research may explore the biological activities of these novel compounds.