Role of neurotransmitters in endosulfan-induced aggressive behaviour in normal and lesioned rats

Normal and lesioned rats exposed to 3 mg/kg i.p. endosulfan for 10 subsequent days showed elevated foot-shock fighting behaviour in septal and nigral brain-lesioned animals. Increased ipsilateral circling was noticed in unilateral-nigral lesioned rats. A marked decrease in locomotor activity and no seizure pattern were recorded in rats treated with chlorpromazine (CPz). Electroencephalographic recording on the tenth day of endosulfan exposure showed high-voltage slow activity (HVSA) with occasional spindles and 5-6 Hz amplitude of 200 microV. In the treated rats an increase in the concentration of dopamine (DA) and a decrease in serotonin (5-HT) were recorded in amygdaloid, septal and nigral brain-lesioned rats.