Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

15.1K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
15.1K
Blood Transfusion01:15

Blood Transfusion

2.6K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.6K
Blood Typing01:10

Blood Typing

3.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
3.2K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

1.8K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
1.8K
Blood Types02:20

Blood Types

23.5K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
23.5K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.1K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventilation and the control of erythropoiesis in high-altitude natives of Chile and Nepal.

American journal of human biology : the official journal of the Human Biology Council·2017
Same author

Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia.

Artificial cells, nanomedicine, and biotechnology·2014
Same author

Oxygen: the poison is in the dose.

Transfusion·2012
Same author

Hemospan: design principles for a new class of oxygen therapeutic.

Artificial organs·2009
Same author

Hemospan improves outcome in a model of perioperative hemodilution and blood loss in the rat: comparison with hydroxyethyl starch.

Journal of cardiothoracic and vascular anesthesia·2008
Same author

Sites of modification of hemospan, a poly(ethylene glycol)-modified human hemoglobin for use as an oxygen therapeutic.

Bioconjugate chemistry·2008
Same journal

Do Differences in Patient-Reported Outcome Measures for Robot-Assisted and Navigated Unicompartmental Knee Replacement Achieve Minimal Clinically Important Differences?

Surgical technology international·2025
Same journal

Clinical and Radiological Results of the Integrated Acetabular MUTARS® RS Cup System in the Revision of Geriatric Patients.

Surgical technology international·2025
Same journal

Does Robotic-Assisted Functional Knee Positioning Result in Better Functional Outcomes One Year After Surgery.

Surgical technology international·2025
Same journal

One-Year Clinical Outcomes Following Anterior Cruciate Ligament Reconstruction Augmented with a Reinforced Bioinductive Implant.

Surgical technology international·2025
Same journal

In-Office Skin Grafting for Lower Extremity Wounds.

Surgical technology international·2025
Same journal

Revision ACL Reconstruction with Hamstring Autograft from the Contralateral Leg With and Without Internal Brace: A Comparative Study.

Surgical technology international·2025
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.1K

Blood Substitutes.

Robert M Winslow1

  • 1Director of Research Laboratory, Letterman Army Institute of Research, Letterman Army Hospital, San Francisco, California.

Surgical Technology International
|June 6, 2017
PubMed
Summary
This summary is machine-generated.

Despite a long-recognized need, no red blood cell transfusion alternatives are approved. Current research focuses on perfluorocarbon-based and hemoglobin-based oxygen carriers due to safety concerns with human blood.

More Related Videos

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.5K
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.5K

Related Experiment Videos

Last Updated: Mar 1, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.1K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.5K
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.5K

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Transfusion Medicine

Background:

  • The need for red blood cell (RBC) transfusion alternatives has been recognized for centuries.
  • Concerns regarding the safety of human blood transfusions have intensified the search for substitutes.
  • No clinically approved RBC substitutes are currently available.

Purpose of the Study:

  • To review the current state of development for RBC transfusion alternatives.
  • To highlight the primary approaches being pursued in the field.
  • To address the ongoing demand for safe and effective blood substitutes.

Main Methods:

  • Review of current research and development in RBC substitute technologies.
  • Focus on two main classes of oxygen-carrying solutions: perfluorocarbons and hemoglobin-based oxygen carriers.
  • Analysis of the progress and challenges in developing these alternatives.

Main Results:

  • Two primary categories of RBC substitutes are under active development: perfluorocarbon-based and hemoglobin-based solutions.
  • Significant progress has been made in the development of these oxygen carriers.
  • Challenges remain in achieving full clinical approval and widespread adoption.

Conclusions:

  • Perfluorocarbon-based and hemoglobin-based oxygen carriers represent the most promising avenues for RBC transfusion alternatives.
  • Continued research and development are crucial to overcome existing hurdles.
  • The successful development of these alternatives could significantly impact transfusion medicine.