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Related Experiment Videos

Reversible ipecac myopathy.

J E Mateer, B J Farrell, S S Chou

    Archives of Neurology
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Ipecac syrup abuse caused muscle weakness due to its toxic effect on muscle fibers. Symptoms and electromyography abnormalities improved after stopping ipecac, confirming its direct myopathic action.

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    Area of Science:

    • Neurology
    • Toxicology
    • Pathology

    Background:

    • Ipecac syrup is commonly used as an emetic but can be abused.
    • Chronic abuse may lead to adverse health effects.
    • Emetine hydrochloride is the active toxic alkaloid in ipecac.

    Observation:

    • A 27-year-old woman presented with painless, nonfatigable, proximal muscle weakness after three years of ipecac syrup abuse.
    • Electromyography (EMG) and muscle biopsy showed myopathic changes.
    • These findings were consistent with experimental emetine myopathy.

    Findings:

    • The patient's muscle weakness and EMG abnormalities significantly improved after discontinuing ipecac syrup.
    • This suggests a direct toxic effect of ipecac on skeletal muscle.

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  • The myopathy observed is attributed to the emetine hydrochloride content.

    • Implications:

    • This case highlights a rare cause of acquired myopathy due to ipecac syrup abuse.
    • It underscores the importance of considering substance abuse in the differential diagnosis of myopathies.
    • Early recognition and cessation of ipecac abuse can lead to recovery of muscle function.