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Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...
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Related Experiment Video

Updated: Mar 1, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
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Landmark Fractional Flow Reserve Trials.

Donald R Lynch1, William F Fearon1

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Interventional Cardiology Clinics
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PubMed
Summary

Fractional flow reserve (FFR) safely guides decisions for moderate coronary lesions. FFR-based strategies reduce unnecessary interventions and improve patient outcomes.

Keywords:
Coronary artery diseaseCoronary ischemiaCoronary physiologyFractional flow reservePercutaneous coronary intervention

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Fractional flow reserve (FFR) is crucial for assessing intermediate coronary lesions.
  • The DEFER trial demonstrated the safety of deferring angioplasty for non-significant moderate lesions.
  • Previous trials established FFR's feasibility in guiding interventions for stable and unstable patients.

Purpose of the Study:

  • To review pivotal trials establishing FFR's role in coronary lesion assessment.
  • To highlight FFR as a key tool for on-the-table functional evaluation.
  • To emphasize the clinical benefits of FFR-guided interventions.

Main Methods:

  • Review of landmark clinical trials, including DEFER and FAME 1.
  • Analysis of FFR's application in physiologic assessment of coronary stenoses.
  • Evaluation of FFR's impact on clinical outcomes and procedural decisions.

Main Results:

  • FFR enables safe deferral of angioplasty for functionally insignificant moderate lesions.
  • FFR-guided interventions improve clinical outcomes in patients with coronary lesions.
  • FFR use reduces the number of unnecessary stenting procedures.

Conclusions:

  • FFR is an established tool for on-the-table functional assessment of coronary lesions.
  • FFR-guided management optimizes treatment strategies and patient care.
  • Clinical trials confirm the value of FFR in interventional cardiology.