Related Experiment Video
Updated: Mar 1, 2026

Murine Model of Hindlimb Ischemia
Published on: January 21, 2009
Acute Limb Ischemia
Bhaskar Purushottam1, Karthik Gujja1, Adrian Zalewski1
1Zena and Michael A. Weiner Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave Levy L. Place, New York, NY 10029, USA.
Acute limb ischemia is a vascular event presenting with sudden decrease in limb perfusion (of <14 days' duration) that threatens limb viability. Acute thrombosis of the native artery or graft makes up the bulk of etiopathogenesis. Prompt revascularization is the cornerstone of management of acute limb ischemia in limbs that have not undergone irreversible tissue and nerve damage. Amputation is performed in patients with irreversible tissue and nerve damage.
Acute limb ischemia is a vascular event presenting with sudden decrease in limb perfusion (of <14 days' duration) that threatens limb viability. Acute thrombosis of the native artery or graft makes up the bulk of etiopathogenesis. Prompt revascularization is the cornerstone of management of acute limb ischemia in limbs that have not undergone irreversible tissue and nerve damage. Amputation is performed in patients with irreversible tissue and nerve damage.
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