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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Is Stenting an Appropriate Therapy in Women Presenting with Acute Coronary Syndrome? A Pathologist's Perspective

Masataka Nakano1, Fumiyuki Otsuka1, Renu Virmani1

  • 1CVPath Institute, 19 Firstfield Road, Gaithersburg, MD 20878, USA.

Interventional Cardiology Clinics
|June 6, 2017
PubMed

Insights

This review examines the pathology of drug-eluting stents (DES) in patients who died suddenly after coronary artery disease treatment. It analyzes findings from early and late time points after stent implantation.

Area of Science:

  • Cardiovascular Pathology
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Percutaneous transluminal coronary angioplasty has treated coronary artery disease for over 30 years.
  • Bare metal stents and drug-eluting stents (DES) have improved clinical outcomes.
  • DES reduce acute vessel closure and restenosis rates.

Purpose of the Study:

  • To review the pathologic findings of coronary stents in patients who died suddenly.
  • To analyze early (<30 days) and late (>30 days) findings after DES implantation.
  • To compare findings in male and female patients.

Main Methods:

  • Review of autopsy findings in patients with coronary stents.
  • Analysis of cases with acute coronary syndrome.
  • Categorization of findings based on time after DES implantation (early vs. late).

Main Results:

  • Pathologic findings related to stent implantation in sudden death cases.
  • Identification of complications associated with DES.
  • Comparison of early and late stent-related pathologies.

Conclusions:

  • Understanding stent pathology is crucial for improving outcomes in coronary artery disease treatment.
  • DES have significantly impacted clinical results, but complications can still occur.
  • Further research into long-term DES performance and pathology is warranted.

Keywords:
Acute coronary syndromeDrug-eluting stentsStentingWomen

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