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Antithrombotic Strategies in Valvular and Structural Heart Disease Interventions: Current Status and Future

Davide Capodanno1, Corrado Tamburino1

  • 1Cardiovascular Department, Ferrarotto Hospital, University of Catania, Via Citelli 6, Catania 95124, Italy; Excellence Through Newest Advances (ETNA) Foundation, Via Citelli 6, Catania 95124, Italy.

Interventional Cardiology Clinics
|June 6, 2017
PubMed

Insights

Antithrombotic prophylaxis is crucial for transcatheter heart procedures. This review details antithrombotic strategies for valvular and structural heart interventions, emphasizing current practices and rationale.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Pharmacology

Background:

  • Antithrombotic prophylaxis is essential for patients undergoing transcatheter interventions for valvular and structural heart disease.
  • Current drug choices and dosages for antiplatelet and anticoagulant agents are largely empirical and operator-dependent.

Purpose of the Study:

  • To outline the rationale behind antithrombotic management in various transcatheter procedures.
  • To describe common strategies for antiplatelet and anticoagulant therapy in these patient populations.

Main Methods:

  • Review of current literature and clinical practices regarding antithrombotic therapy.
  • Discussion of specific transcatheter interventions including TAVI, MitraClip, PFO closure, and ASD closure.

Main Results:

  • Antithrombotic strategies vary significantly based on the specific procedure and patient factors.
  • Operator discretion plays a major role in current antithrombotic management.

Conclusions:

  • Standardized antithrombotic protocols are needed for transcatheter valvular and structural heart interventions.
  • Further research is required to optimize antithrombotic therapy and improve patient outcomes.

Keywords:
BivalirudinDual antiplatelet therapyHeparinTAVI

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