Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Control of spiral breakup by an alternating advective field.

The Journal of chemical physics·2006

Same author

Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3.

Clinical cancer research : an official journal of the American Association for Cancer Research·2006

Same author

New rod-plate anterior instrumentation for thoracolumbar/lumbar scoliosis: biomechanical evaluation compared with dual-rod and single-rod with structural interbody support.

Spine·2006

Same author

Dimeric ansamycins--a new class of antitumor Hsp90 modulators with prolonged inhibitory activity.

International journal of cancer·2006

Same author

A unified mode of epigenetic gene silencing: RNA meets polycomb group proteins.

RNA biology·2006

Same author

Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging.

Journal of cellular physiology·2006

Same journal

Retraction Notice: Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies.

Technology and health care : official journal of the European Society for Engineering and Medicine·2026

Same journal

The role of digital resources in surgical education: An analysis of YouTube videos on dynamic stabilization.

Technology and health care : official journal of the European Society for Engineering and Medicine·2026

Same journal

Behavioral patterns in iGaming across territories: Psychiatric and AI-driven insights via the internet of behavior.

Technology and health care : official journal of the European Society for Engineering and Medicine·2026

Same journal

Leveraging personal health records for early heart failure risk prediction through AI-driven modeling.

Technology and health care : official journal of the European Society for Engineering and Medicine·2026

Same journal

From data to prevention: A systematic review of artificial intelligence applications in sports injury prediction.

Technology and health care : official journal of the European Society for Engineering and Medicine·2026

Same journal

Leadership styles and work outcome in healthcare sector: Insights from bibliometric analysis.

Technology and health care : official journal of the European Society for Engineering and Medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 1, 2026

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time

Published on: July 1, 2014

Potential for false positive results from multi-voxel pattern analysis on functional imaging data.

Zuo Zhang^1,1, Youhao Jiang^2,3,1, Yaoru Sun¹

¹Department of Computer Science and Technology, Tongji University, Shanghai, China.

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine

|June 7, 2017

Summary

This summary is machine-generated.

Multi-voxel pattern analysis (MVPA) can yield false positives in brain imaging studies. Researchers suggest using control regions to validate findings, rather than just chance-level comparisons, to ensure accuracy.

Keywords:

Multi-voxel pattern analysis brain imaging false positive functional MRI

More Related Videos

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Cross-Modal Multivariate Pattern Analysis

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

Related Experiment Videos

Last Updated: Mar 1, 2026

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time

Published on: July 1, 2014

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Cross-Modal Multivariate Pattern Analysis

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

Area of Science:

Neuroscience
Cognitive Neuroscience
Neuroimaging

Background:

Multi-voxel pattern analysis (MVPA) is a key technique for studying cognitive processes using functional brain imaging.
Previous research has largely overlooked the potential for MVPA's high sensitivity to produce false positive results.

Purpose of the Study:

To investigate the potential for false positives in Multi-voxel pattern analysis (MVPA).
To examine how varying parameters affect MVPA results and the emergence of false positives.

Main Methods:

MVPA was applied to a public functional MRI dataset focusing on neural object category encoding.
Analysis involved manipulating the number of voxels within regions of interest (ROIs) and the number of object categories.

Main Results:

Classification accuracy increased with a greater number of voxels.
False positives were detected in the primary auditory cortex and white matter ROIs, areas not expected to process object information.

Conclusions:

MVPA classification accuracy may be artificially inflated due to method sensitivity.
Future MVPA studies should incorporate control ROIs and compare target ROI accuracy against control ROI accuracy, not just chance levels.