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A brief review: adipose-derived stem cells and their therapeutic potential in cardiovascular diseases

Teng Ma1, Jiacheng Sun1, Zhenao Zhao1

  • 1Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, No.899, Pinghai Road, Suzhou, 215006, China.

Stem Cell Research & Therapy
|June 7, 2017
PubMed

Insights

Adipose-derived stem cells (ADSCs) show promise for cardiovascular disease treatment by differentiating and secreting factors for cardiac regeneration. Research is ongoing to improve ADSC survival and efficacy in clinical trials for myocardial infarction.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Stem Cell Biology

Background:

  • Adipose-derived stem cells (ADSCs) are a readily accessible source of adult stem cells.
  • ADSCs possess the potential to differentiate into cardiovascular cell types.
  • These cells are recognized for their therapeutic potential in treating cardiovascular diseases.

Purpose of the Study:

  • To review the differentiation and paracrine functions of ADSCs.
  • To discuss strategies for enhancing ADSC therapeutic efficacy.
  • To summarize the current clinical applications of ADSCs in cardiovascular disease.

Main Methods:

  • Review of existing literature on ADSC differentiation and function.
  • Analysis of studies investigating methods to improve ADSC survival and engraftment.
  • Examination of data from Phase I and II clinical trials for ADSC therapy in myocardial infarction.

Main Results:

  • ADSCs can differentiate into cardiomyocytes, vascular smooth muscle cells, and endothelial cells.
  • ADSCs secrete paracrine factors that promote neovascularization, reduce apoptosis, and inhibit fibrosis.
  • Engineering and pharmacological approaches are being developed to overcome limitations like low survival and engraftment.

Conclusions:

  • ADSCs hold significant potential for cardiac regeneration and cardiovascular disease treatment.
  • Ongoing research and clinical trials are focused on optimizing ADSC therapy.
  • Further studies are needed to fully establish the safety and efficacy of ADSCs in clinical practice.

Keywords:
Adipose-derived stem cellsCardiovascular diseasesDifferentiationParacrine effectStem cell transplantation

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