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Modafinil in schizophrenia: is the risk worth taking?
Daniel Neto1,2, Carla Spínola1, Joaquim Gago1,2
1Departamento de Psiquiatria e Saúde Mental, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal.
BMJ Case Reports
|June 7, 2017
Summary
Modafinil shows potential for treating schizophrenia negative symptoms, but case studies reveal risks. Further research is essential to confirm efficacy and safety in patients with schizophrenia.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Schizophrenia presents with positive and negative symptoms, with negative symptoms being particularly challenging to treat.
- Current treatment options for negative symptoms of schizophrenia are limited, necessitating exploration of novel therapeutic strategies.
Observation:
- Modafinil, a wakefulness-promoting agent, has been investigated in small trials alongside antipsychotic treatments for schizophrenia.
- This report details three case studies involving the use of modafinil in patients with schizophrenia.
Findings:
- Two patients in the case series developed positive symptoms after modafinil administration.
- One patient experienced renal impairment, indicating a potential safety concern.
Implications:
- These findings suggest that while modafinil may warrant further investigation for schizophrenia, its use requires careful consideration of potential adverse effects.
- Additional controlled studies are crucial to establish the efficacy and safety profile of modafinil in the management of schizophrenia, particularly concerning negative symptoms and renal function.
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