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MMP2 and MMP9 associate with crescentic glomerulonephritis.
Tessa M Phillips1, Mitali Fadia1, Tom N Lea-Henry2
1Department of Anatomical Pathology, The Canberra Hospital, Canberra, ACT, Australia.
Clinical Kidney Journal
|June 7, 2017
Summary
Matrix metalloproteinases (MMP) 2 and 9 are expressed in active lupus nephritis (LN) with cellular crescents. These enzymes may play a role in the development of kidney lesions in this autoimmune disease.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease.
- Lupus nephritis (LN) is a frequent and diverse renal manifestation of SLE.
- Matrix metalloproteinases (MMPs), specifically MMP2 and MMP9, degrade glomerular basement membrane collagen and are implicated in LN.
Purpose of the Study:
- To investigate the expression patterns of MMP2 and MMP9 in various classes of lupus nephritis.
- To correlate MMP2 and MMP9 expression with specific histological features of LN, particularly extracapillary proliferation.
Main Methods:
- Immunohistochemistry was used to detect MMP2 and MMP9 expression.
- Renal biopsy specimens from patients with LN (Class III, IV, V), other glomerulonephritides, and normal controls were analyzed.
Main Results:
- MMP2 and MMP9 expression was detected in active cellular and fibrocellular crescents in LN.
- Expression was not observed in inactive fibrous crescents or with mesangial proliferation.
- MMP2/MMP9 expression in crescents was independent of the underlying glomerulonephritis type.
Conclusions:
- MMP2 and MMP9 are associated with active extracapillary proliferation in lupus nephritis.
- Further research is needed to elucidate their precise roles in glomerular repair, immune response, or as markers of epithelialization.
Keywords:
crescentic glomerulonephritisglomerulonephritisimmunoglobulin A nephropathymetalloproteinasesystemic lupus erythematosusMore Related Videos
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