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Related Concept Videos

Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Drug Administration and Therapy Phases: Overview01:26

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Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
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In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
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Drug development: Lessons from nature.

Sunil Mathur1, Clare Hoskins2

  • 1Molecular Drug Research Laboratory, Edinburgh Napier University, Edinburgh EH11 4BN, UK.

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|June 7, 2017
PubMed
Summary
This summary is machine-generated.

Natural products, especially from plants, have long been used for medicine. Modern science now explores their chemical diversity for new drug discovery and therapeutic applications.

Keywords:
combinatorial chemistrydrug discoveryhigh throughput screeningnatural products

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Area of Science:

  • Pharmacology
  • Medicinal Chemistry
  • Natural Products Chemistry

Background:

  • Natural products have historically served as a primary source for therapeutic agents.
  • Plant-derived compounds and microbial natural products were utilized long before modern medicine.
  • The efficacy of natural products is intrinsically linked to their chemical, biochemical, and synthetic properties.

Purpose of the Study:

  • To highlight the enduring importance of natural products in medicine.
  • To explore the integration of modern scientific disciplines with natural product research.
  • To leverage the chemical and structural diversity of natural products for therapeutic advancements.

Main Methods:

  • Utilizing advancements in molecular and cellular biology.
  • Applying modern analytical chemistry techniques.
  • Employing pharmacological studies to assess therapeutic potential.

Main Results:

  • Harnessing the unique properties of natural products.
  • Exploiting the chemical and structural diversity and biodiversity of natural products.
  • Identifying novel molecular entities through the rearrangement of natural product structures.

Conclusions:

  • Natural products remain a crucial resource for drug discovery.
  • Modern scientific approaches enhance the exploitation of natural product potential.
  • Modification of natural product structures can lead to clinically useful therapies.