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Updated: Mar 1, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
Published on: February 14, 2011
DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis
Alice M Ribeiro1, André C Amaral2, Maria Sueli S Felipe1,3
1Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil.
Abstract:
The conventional treatment for fungal diseases usually shows long periods of therapy and the high frequency of relapses and sequels. New strategies of the treatment are necessary. We have shown that the Mycobacterium leprae HSP65 gene can be successfully used as therapy against murine Paracoccidioidomycosis (PCM). Here, we described the methodology of DNAhsp65 immunotherapy in mice infected with the dimorphic fungus Paracoccidioides brasiliensis, one of PCM agent, evaluating cytokines levels, fungal burden, and lung injury. Our results provide a new prospective on the immunotherapy of mycosis.
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