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Updated: Mar 1, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Idiotypic Antifungal Vaccination: Immunoprotection by Antiidiotypic Antibiotic Antibodies
Luciano Polonelli1, Walter Magliani2, Stefania Conti2
1Unit of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T.), Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125, Parma, Italy. luciano.polonelli@unipr.it.
Abstract:
As implied by the idiotypic network theory, the interaction between the functional epitope of a microbicidal molecule (X) and its specific cell-wall receptor (RX) on sensitive microorganisms may be imaged by the bond between the idiotype (Id) of a neutralizing monoclonal antibody (anti-X Ab) and its anti-idiotype (anti-Id) X-like Ab (anti-anti-X Ab). Consequently, anti-X Ab Id may mimic RX acting as a vaccine (idiotypic vaccination) for the elicitation of protective anti-Id Abs with antibiotic activity (antibiobodies).
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