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Vaccination with Phage-Displayed Antigenic Epitope.

Yicun Wang1, Li Wang2

  • 1Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, China.

Methods in Molecular Biology (Clifton, N.J.)
|June 7, 2017
PubMed
Summary

Phage-displayed antigenic epitopes offer a safe vaccine delivery system. This study demonstrates their effectiveness against Candida albicans infection in mice.

Keywords:
EpitopePhage displayVaccine

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Area of Science:

  • Immunology
  • Vaccinology
  • Microbiology

Background:

  • Phage display technology enables the presentation of antigenic epitopes.
  • These epitopes can elicit both humoral and cell-mediated immune responses.
  • This approach holds potential for developing safe and tolerable vaccines.

Purpose of the Study:

  • To evaluate the efficacy of a phage-displayed antigenic epitope as a vaccine against Candida albicans infection.
  • To assess the immune response induced by M13 phage-displayed SLAQVKYTSASSI.

Main Methods:

  • Vaccination of BALB/c mice with M13 phage displaying the SLAQVKYTSASSI epitope.
  • Assessment of immune responses and protection against Candida albicans challenge.

Main Results:

  • The phage-displayed epitope successfully induced immune responses.
  • Vaccination provided protection against Candida albicans infection in mice.

Conclusions:

  • Phage-displayed antigenic epitopes are a promising platform for vaccine development.
  • This method offers a safe and effective strategy for combating Candida albicans infections.