Displacement of striatal 5-hydroxytryptamine by dopamine released from endogenous stores

Combined treatment with amfonelic acid and neuroleptics caused a considerable loss of striatal, but not cortical 5-hydroxytryptamine (5-HT) in rats. This could be prevented by pretreatment with the specific 5-HT uptake inhibitor, citalopram. The results are best explained by the assumption that the combined treatment with amfonelic acid and neuroleptic had massively released dopamine into the synaptic cleft, and a part of this had been taken up into the 5-HT neurons by the 5-HT uptake mechanism and displaced the indoleamine.