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Updated: Mar 1, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
Published on: September 16, 2014
A DNA-Based Label-Free Artificial Tongue for Pattern Recognition of Metal Ions
Hao Qiu1,2, Fang Pu1, Xiang Ran1,2
1Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China), Fax:(+86) 0431-85262625.
Abstract:
An array-based sensing method offers several advantages for detecting various analytes. DNA molecules as sensor elements have attracted considerable interest owing to their unique properties. Here, a label-free sensor array using DNA and commercially available dyes to differentiate metal ions is reported. Based on the different interactions between dye-bound DNA and metal ions, the fluorescence intensities of the sensor elements are changed to different degrees. In this way, fourteen metal ions can be efficiently distinguished by principal component analysis (PCA) and hierarchical cluster analysis (HCA). A highly sensitive discrimination of metal ions with 92.8 % identification accuracy can be achieved. The present work provides a simple and convenient method for the construction of a DNA-based sensor array.
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