Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of PAM4 in the management of pancreatic cancer: diagnosis, radioimmunodetection, and radioimmunotherapy.

Journal of immunology research·2014
Same author

Insulin-like growth factor-2 enhances functions of antigen (Ag)-specific regulatory B cells.

The Journal of biological chemistry·2014
Same author

Therapeutic effects of PADRE-BAFF autovaccine on rat adjuvant arthritis.

BioMed research international·2014
Same author

[Effects of rhG-CSF mobilization on the polarization and migration of donor's CD4(+)T lymphocytes].

Zhongguo shi yan xue ye xue za zhi·2014
Same author

Graphene functionalized porous Au-paper based electrochemiluminescence device for detection of DNA using luminescent silver nanoparticles coated calcium carbonate/carboxymethyl chitosan hybrid microspheres as labels.

Biosensors & bioelectronics·2014
Same author

The novel Shewanella putrefaciens-infecting bacteriophage Spp001: genome sequence and lytic enzymes.

Journal of industrial microbiology & biotechnology·2014

Related Experiment Video

Updated: Mar 1, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.6K

Understanding neurodevelopmental disorders using human pluripotent stem cell-derived neurons.

Claudia Tamburini1, Meng Li1

  • 1Neuroscience and Mental Health Research Institute, School of Medicine and School of Biosciences, Cardiff University, Cardiff, United Kingdom.

Brain Pathology (Zurich, Switzerland)
|June 7, 2017
PubMed
Summary

Induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 genome editing are revolutionizing psychiatric disorder research. These technologies enable the creation of patient-specific in vitro models, advancing our understanding of neurodevelopmental origins and paving the way for new treatments.

Keywords:
disease modelinghuman pluripotent stem cellsneurodevelopmentneuronal differentiationpsychiatric disorders

More Related Videos

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells
10:49

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

Published on: April 14, 2013

11.4K
A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
09:30

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

19.1K

Related Experiment Videos

Last Updated: Mar 1, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.6K
The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells
10:49

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

Published on: April 14, 2013

11.4K
A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
09:30

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

19.1K

Area of Science:

  • Neuroscience
  • Genetics
  • Stem Cell Biology

Background:

  • Traditional research models for psychiatric disorders are limited.
  • Induced pluripotent stem cells (iPSCs) provide a patient-specific, renewable cell source.
  • iPSCs can be differentiated into various cell types for in vitro disease modeling.

Purpose of the Study:

  • To review neuronal differentiation protocols for iPSC-based psychiatric disorder models.
  • To assess progress in iPSC models for schizophrenia, autism spectrum disorders, and bipolar disorder.
  • To discuss the impact of CRISPR/Cas9 genome editing on disease modeling.

Main Methods:

  • Review of existing literature on iPSC differentiation protocols.
  • Analysis of current iPSC-based models for major psychiatric disorders.
  • Evaluation of CRISPR/Cas9 applications in psychiatric disease modeling.

Main Results:

  • iPSCs offer a powerful platform for creating in vitro models of psychiatric disorders.
  • CRISPR/Cas9 facilitates genetic manipulation for disease causality studies.
  • Significant contributions to understanding the developmental origins of psychiatric disorders have been made.

Conclusions:

  • iPSC reprogramming and CRISPR/Cas9 technology are crucial for advancing psychiatric disorder research.
  • Establishing causality of cellular pathology is enhanced by genome editing.
  • Future research should focus on identifying shared etiological mechanisms for novel treatment development.