Related Experiment Videos
The effect of formulation on oesophageal transit
The Journal of Pharmacy and Pharmacology
|February 1, 1985
Summary
Drug formulation significantly impacts oesophageal transit time. Different capsule sizes, weights, and film coatings affect how quickly dosage forms move through the oesophagus, influencing ulceration risk.
Area of Science:
- Gastroenterology
- Pharmaceutics
- Radiology
Background:
- Oesophageal transit is crucial for drug delivery.
- Drug formulations can influence transit and cause oesophageal injury.
Purpose of the Study:
- To investigate the effect of various drug formulations on oesophageal transit.
- To determine how factors like size, weight, and coating impact transit speed.
Main Methods:
- Barium sulphate transit measured via fluoroscopy in 175 subjects.
- Evaluated small/large, heavy/light capsules, and film-coated/plain oval tablets.
- Studies conducted in both erect and supine positions.
Main Results:
- Large capsules, especially heavy ones, showed faster oesophageal transit than plain tablets.
- Film coating significantly improved oval tablet transit.
- Transit times varied based on subject position (erect vs. supine) and formulation characteristics.
Conclusions:
- Drug formulation is a significant determinant of oesophageal transit.
- Understanding these effects is vital for preventing drug-induced oesophageal ulceration.