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Force-displacement measurements in tableting.

G Ragnarsson, J Sjögren

The Journal of Pharmacy and Pharmacology

|March 1, 1985

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Particle interaction significantly impacts net work (NETW) during compaction but not yield pressure. Yield pressure is a better indicator of material deformation properties, while NETW is sensitive to variations in compaction behavior.

Area of Science:

Materials Science
Pharmaceutical Engineering
Powder Technology

Background:

Particle interactions like friction and bonding influence powder compaction.
Heckel plots and net work (NETW) are used to analyze compaction behavior.

Purpose of the Study:

To investigate the effect of particle interaction on NETW and Heckel plots.
To determine the suitability of NETW and yield pressure for evaluating material properties.

Main Methods:

Varying particle size, lubrication, and moisture content.
Analyzing compaction data using Heckel plots and calculating NETW.
Assessing the sensitivity of NETW and yield pressure to particle interactions.

Main Results:

Related Experiment Videos

NETW was highly sensitive to particle interactions (friction and bonding).
Yield pressure showed less dependence on particle interactions.
NETW demonstrated high reproducibility and low dependence on die wall conditions.

Conclusions:

Yield pressure is a more reliable measure for evaluating material deformation properties.
NETW is a sensitive indicator for inter-lot variations in compaction behavior.
NETW is not a suitable measure for assessing the plastic properties of a substance.