Related Experiment Video

Updated: Mar 1, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.5K

Effects of intraoperative liberal fluid therapy on postoperative nausea and vomiting in children-A randomized

Vighnesh Ashok1, Indu Bala1, Neerja Bharti1

  • 1Department of Anesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Paediatric Anaesthesia
|June 7, 2017
PubMed

Insights

Liberal intraoperative fluid therapy significantly reduced postoperative nausea and vomiting (PONV) in children. This approach also decreased thirst and increased parental satisfaction without complications.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery
  • Critical Care Medicine

Background:

  • Postoperative nausea and vomiting (PONV) is a significant complication in pediatric surgery.
  • Perioperative fluid management is a potential strategy to mitigate PONV in children.

Purpose of the Study:

  • To evaluate the impact of liberal intraoperative fluid therapy on PONV in pediatric patients.
  • To compare the incidence of PONV between restricted and liberal fluid administration groups.

Main Methods:

  • A randomized trial involving 150 children (3-7 years) undergoing lower abdominal or penile surgery.
  • Two groups received different Ringer's lactate infusion rates: restricted (10 mL/kg/h) and liberal (30 mL/kg/h).
  • PONV, antiemetic use, thirst, and parental satisfaction were assessed over 24 hours postoperatively.

Main Results:

  • The liberal fluid group showed a significantly lower incidence of PONV (27.4%) compared to the restricted group (45.8%).
  • Children in the restricted group reported significantly more thirst (83%) than those in the liberal group (17%).
  • Parental satisfaction was higher in the liberal fluid group, with no attributed complications.

Conclusions:

  • Liberal intraoperative fluid therapy effectively reduces PONV in pediatric patients undergoing lower abdominal surgery.
  • This fluid strategy improves postoperative comfort and satisfaction in children.
Abstract

Keywords:
anesthesia, generalchildrencrystalloid solutionsfluid therapypostoperative nausea and vomitingthirst

More Related Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K
Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation07:15

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

Published on: December 5, 2025

465

Related Concept Videos

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
879
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
983
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
691
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
744