Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VEGF-D Dependent IFNγ Production by Natural Killer Cells in Lymphangioleiomyomatosis.

Journal of cellular immunology·2026
Same author

Alveolar-Basal Intermediates Drive Pulmonary Fibrosis via Coordination of a Pro-Fibrotic Signaling Niche in Silicosis.

bioRxiv : the preprint server for biology·2026
Same author

Hyperactivation of mTORC1 signaling mediates folliculin deficiency-induced pulmonary cyst formation in Birt-Hogg-Dubé syndrome.

The Journal of clinical investigation·2026
Same author

Clinical characteristics of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.

ERJ open research·2026
Same author

High-Throughput Proteomics in Lymphangioleiomyomatosis: Premelanosome Protein as a Diagnostic Biomarker, Construction of a Diagnosis Score, and Evidence of Neutrophil Involvement.

Chest·2026
Same author

Pulmonary Alveolar Microlithiasis: A Disorder of Pulmonary Phosphate Homeostasis.

Clinics in chest medicine·2025

Related Experiment Video

Updated: Mar 1, 2026

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

Published on: January 20, 2017

9.7K

Dendritic Cell Trafficking and Function in Rare Lung Diseases.

Huan Liu1, Claudia Jakubzick2, Andrew R Osterburg1

  • 11 Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, Ohio.

American Journal of Respiratory Cell and Molecular Biology
|June 7, 2017
PubMed
Summary

Dendritic cells (DCs) are crucial immune cells in the lungs. New research highlights their roles in both common and rare lung diseases, offering insights into disease mechanisms.

Keywords:
dendritic cellsfibrosishistiocytosishypersensitivity pneumonitissarcoidosis

More Related Videos

Isolation of Mouse Lung Dendritic Cells
09:04

Isolation of Mouse Lung Dendritic Cells

Published on: November 22, 2011

29.9K
Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

15.4K

Related Experiment Videos

Last Updated: Mar 1, 2026

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

Published on: January 20, 2017

9.7K
Isolation of Mouse Lung Dendritic Cells
09:04

Isolation of Mouse Lung Dendritic Cells

Published on: November 22, 2011

29.9K
Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

15.4K

Area of Science:

  • Immunology
  • Pulmonary Medicine
  • Cell Biology

Background:

  • Dendritic cells (DCs) are specialized immune cells vital for antigen presentation and innate immune responses.
  • Pulmonary DC biology has been extensively studied in common lung diseases like asthma, infection, and cancer.
  • Novel reagents and models have advanced the understanding of distinct lung DC populations and their functions.

Purpose of the Study:

  • To review DC development, trafficking, and effector functions in the lung.
  • To discuss the role of DCs in the pathogenesis of rare lung diseases.
  • To explore how altered DC pathways contribute to rare lung disease development.

Main Methods:

  • Review of existing literature on dendritic cell biology in the lung.
  • Analysis of recent advances in DC research, including new techniques and animal models.
  • Synthesis of data linking DC functions to rare pulmonary diseases.

Main Results:

  • DCs play a significant role in both innate and adaptive immunity within the lung.
  • Distinct DC populations exist in the lung, with specific roles in disease pathogenesis.
  • Altered DC development, migration, or function are implicated in rare lung diseases.

Conclusions:

  • Enhanced understanding of pulmonary DC biology provides new avenues for investigating lung diseases.
  • Dendritic cells are increasingly recognized as key players in the pathogenesis of rare lung conditions.
  • Targeting DC pathways may offer therapeutic strategies for rare pulmonary diseases.