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Updated: Mar 1, 2026
Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
Published on: March 31, 2023
Atelocollagen Enhances the Healing of Rotator Cuff Tendon in Rabbit Model
Dong-Sam Suh1, Jun-Keun Lee1, Ji-Chul Yoo1
1RMS Research Institute, Seoul, Republic of Korea.
Background:
Failure of rotator cuff healing is a common complication despite the rapid development of surgical repair techniques for the torn rotator cuff.
Purpose:
To verify the effect of atelocollagen on tendon-to-bone healing in the rabbit supraspinatus tendon compared with conventional cuff repair.
Study Design:
Controlled laboratory study.
Methods:
A tear of the supraspinatus tendon was created and repaired in 46 New Zealand White rabbits. They were then randomly allocated into 2 groups (23 rabbits per group; 15 for histological and 8 for biomechanical test). In the experimental group, patch-type atelocollagen was implanted between bone and tendon during repair; in the control group, the torn tendon was repaired without atelocollagen. Each opposite shoulder served as a sham (tendon was exposed only). Histological evaluation was performed at 4, 8, and 12 weeks. Biomechanical tensile strength was tested 12 weeks after surgery.
Results:
Histological evaluation scores of the experimental group (4.0 ± 1.0) were significantly superior to those of the control group (7.7 ± 2.7) at 12 weeks ( P = .005). The load to failure was significantly higher in the experimental group (51.4 ± 3.9 N) than in the control group (36.4 ± 5.9 N) ( P = .001).
Conclusion:
Histological and biomechanical studies demonstrated better results in the experimental group using atelocollagen in a rabbit model of the supraspinatus tendon tear.
Clinical Relevance:
Atelocollagen patch could be used in the cuff repair site to enhance healing.
