Related Experiment Video
Updated: Mar 1, 2026
07:42
Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
18.6K
Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy
Jiri Grim1, Alena Ticha2,3, Radomir Hyspler4,5
1Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech. grimj@lfhk.cuni.cz.
Nutrients
|June 8, 2017
Summary
Chemotherapy-induced peripheral neuropathy (CIPN) affects 60% of patients. Lower vitamin D and higher saturated fatty acid levels are linked to CIPN. Vitamin D supplementation may prevent this side effect.
Area of Science:
- Oncology
- Neurology
- Nutritional Science
Background:
- Chemotherapy often causes peripheral neuropathy, a debilitating side effect with no current preventative treatments.
- Nutritional deficiencies are suspected risk factors for chemotherapy-induced peripheral neuropathy (CIPN).
Purpose of the Study:
- To identify nutritional risk factors for chemotherapy-induced peripheral neuropathy (CIPN).
- To explore potential nutritional supplementation strategies for preventing CIPN.
Main Methods:
- Analyzed 70 patients undergoing paclitaxel chemotherapy.
- Assessed risk factors including vitamin B1, B6, D, and fatty acid levels.
- Compared nutritional markers between patients with and without CIPN.
Main Results:
- CIPN occurred in 60% of patients.
- Significantly lower vitamin D levels were observed in patients with CIPN (25.6 nmol/L) compared to those without (38.2 nmol/L).
- Significantly higher saturated fatty acid levels were found in patients with CIPN (34.2 Area %) versus those without (32.6 Area %).
Conclusions:
- Dietary intake of saturated fatty acids may influence CIPN development.
- Vitamin D deficiency is a significant risk factor for CIPN.
- Vitamin D supplementation prior to chemotherapy shows potential as a neuroprotective strategy for CIPN prophylaxis.
Related Concept Videos
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
691
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
691
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
744
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
744
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
983
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
983
01:24Drug Toxicity: Risk factors
60
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
60
01:27Nursing Ethical Principles II
2.3K
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
2.3K
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
864
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
864