Related Experiment Video
Updated: Mar 1, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
The Role of Caveolin 1 in HIV Infection and Pathogenesis
1Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32611, USA. mergiaa@ufl.edu.
Abstract:
Caveolin 1 (Cav-1) is a major component of the caveolae structure and is expressed in a variety of cell types including macrophages, which are susceptible to human immunodeficiency virus (HIV) infection. Caveolae structures are present in abundance in mechanically stressed cells such as endothelial cells and adipocytes. HIV infection induces dysfunction of these cells and promotes pathogenesis. Cav-1 and the caveolae structure are believed to be involved in multiple cellular processes that include signal transduction, lipid regulation, endocytosis, transcytosis, and mechanoprotection. Such a broad biological role of Cav-1/caveolae is bound to have functional cross relationships with several molecular pathways including HIV replication and viral-induced pathogenesis. The current review covers the relationship of Cav-1 and HIV in respect to viral replication, persistence, and the potential role in pathogenesis.
More Related Videos
11:45Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
Published on: March 8, 2012
14:23A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
Related Concept Videos
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Intralumenal Vesicles and Multivesicular Bodies
Mechanisms of Retrovirus-induced Cancers
Size and Structure of Viral Genomes
Retrovirus Life Cycles
Intracellular Movement of Viruses and Bacteria