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Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases

Werner J Geldenhuys1, Ahmad Hanif2, June Yun3

  • 1Department of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, USA. werner.geldenhuys@hsc.wvu.edu.

Molecules (Basel, Switzerland)
|June 8, 2017
PubMed

Insights

Adenosine receptors are key targets for treating cardiovascular diseases. This review explores ligands that modulate these receptors, focusing on structural impacts on drug efficacy for vascular conditions.

Area of Science:

  • Pharmacology
  • Medicinal Chemistry
  • Cardiovascular Science

Background:

  • Cardiovascular diseases are a leading cause of death globally.
  • Adenosine receptors, a class of G-protein coupled receptors, are implicated in various physiological and pathological cardiovascular processes.
  • These receptors are recognized as promising therapeutic targets for a range of conditions.

Purpose of the Study:

  • To review identified adenosine receptor ligands.
  • To evaluate their effects on the vascular system.
  • To analyze structure-activity relationships for ligand potency and efficacy.

Main Methods:

  • Literature review of adenosine receptor ligands.
  • Analysis of clinical and medicinal chemistry data.
  • Evaluation of structure-activity relationships impacting potency and efficacy.

Main Results:

  • Numerous adenosine receptor ligands have been identified.
  • These ligands demonstrate significant effects on vascular system physiology and pathology.
  • Specific structural modifications correlate with altered ligand potency and efficacy.

Conclusions:

  • Adenosine receptors are a viable therapeutic target for cardiovascular diseases.
  • Medicinal chemistry approaches focusing on structural modifications can optimize ligand development.
  • Further research into adenosine receptor modulation may yield novel treatments for vascular diseases and obesity.

Keywords:
atherosclerosiscardiac deathmyocardial infarctionvascular tone

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