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Mosapride combined with probiotics on gastrointestinal function and growth in premature infants

Ai-Mei Zhang1, Zhi-Qun Sun1, Li-Ming Zhang1

  • 1Department of Pediatrics, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

Experimental and Therapeutic Medicine
|June 8, 2017
PubMed

Insights

Mosapride combined with probiotics significantly improves gastrointestinal function and growth in premature infants. This combination therapy reduces feeding intolerance and promotes faster recovery and development in preterm infants.

Area of Science:

  • Neonatal Medicine
  • Gastroenterology
  • Microbiology

Background:

  • Premature infants often experience gastrointestinal (GI) dysfunction, leading to feeding intolerance (FI) and impaired growth.
  • Probiotics and prokinetic agents like mosapride are used to manage GI issues in neonates, but their combined effects require further investigation.

Purpose of the Study:

  • To investigate the efficacy of mosapride combined with probiotics in improving GI function, growth, and development in premature infants.
  • To compare the effects of two different probiotic formulations (Medilac-Vita and Bioflor) when used with mosapride.

Main Methods:

  • A randomized controlled trial involving 240 premature infants divided into three groups: routine care, routine care plus mosapride and Medilac-Vita (B. subtilis, E. faecium), and routine care plus mosapride and Bioflor (Saccharomyces boulardii).
  • Measurements included gastrin and bilirubin levels, jaundice duration, weight gain, head circumference, feeding intolerance incidence, gastric retention, and incidence of other neonatal complications.

Main Results:

  • Groups receiving mosapride and probiotics showed significantly higher gastrin levels and faster bilirubin decline compared to the control group.
  • Enhanced weight growth rate, head circumference, and shorter recovery time from weight loss were observed in infants treated with mosapride and probiotics.
  • Lower incidence rates of gastric retention, feeding intolerance, neonatal hyperbilirubinemia, parenteral nutrition-associated cholestasis, necrotizing enterocolitis, and neonatal sepsis were noted in the intervention groups.

Conclusions:

  • Combined administration of mosapride and probiotics is effective in reducing feeding intolerance and promoting nutrient absorption in premature infants.
  • This therapeutic approach supports the development and recovery of early physiological weight loss in preterm infants.
  • The combination therapy contributes to better overall growth and development and reduces the incidence of serious neonatal complications.

Keywords:
gastrointestinal functiongrowth and developmentmosapridepremature infantprobiotics

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