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Accelerometer-Measured Daily Activity in Heart Failure With Preserved Ejection Fraction: Clinical Correlates and
David Snipelisky1, Jacob Kelly1, James A Levine1
1From the Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (D.S., R.Z., M.M.R.); Duke Clinical Research Institution, Duke University, Durham, NC (J.K., K.J.A., S.E.M., G.M.F., A.F.H.); Endocrine Research Unit, Mayo Clinic, Phoenix, AZ (J.A.L., G.A.K.); and Brigham and Women's Hospital, Boston, MA (E.B.).
Circulation. Heart Failure
|June 8, 2017
Summary
Daily physical activity in heart failure with preserved ejection fraction (HFpEF) patients varies by characteristics and correlates with HF severity. Accelerometry offers a unique way to track intervention impacts on functional status.
Area of Science:
- Cardiology
- Gerontology
- Physical Medicine
Background:
- Daily physical activity assessed by accelerometers is a novel method for evaluating interventions in heart failure (HF) patients.
- This study investigated daily activity in HF with preserved ejection fraction (HFpEF) and its correlation with HF severity.
Purpose of the Study:
- To hypothesize that daily activity varies by patient characteristics in HFpEF.
- To determine if daily activity correlates with established measures of HF severity.
Main Methods:
- Ancillary study of the NEAT-HFpEF trial (NCT02053493).
- Assessed average daily accelerometer units (ADAU) and hours active per day over 14 days in 110 HFpEF patients before treatment.
- Correlated ADAU and active hours with baseline patient characteristics and HF severity measures.
Main Results:
- Baseline ADAU was negatively associated with age, female sex, height, and BMI, explaining 28% of variability.
- Lower ADAU correlated with HF hospitalization, orthopnea, diabetes, anemia, beta-blocker use, higher ejection fraction, and worse NYHA class, QoL, 6MWD, and NT-proBNP.
- No significant associations were found between changes in daily activity and changes in standard functional assessments with isosorbide mononitrate.
Conclusions:
- Daily activity is a measure of HF-related and global functional status in HFpEF.
- Changes in daily activity may offer unique insights into intervention effects on functional status compared to intermittent assessments.
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