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PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway

Mengran Qiao1, Mian Wu2, Ronghua Shi3

  • 1CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Cell and Molecular Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science & Technology of China, Hefei, 230027, China.

Scientific Reports
|June 8, 2017
PubMed
Summary

PHLDA3, a p53 target gene, blocks induced pluripotent stem cell (iPSC) generation by activating the Akt-GSK3β pathway. Oct4 also regulates PHLDA3, revealing its role in the somatic cell reprogramming network.

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