Achieving a satisfactory clinical and biochemical response in antiphospholipid syndrome and severe thrombocytopenia

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Donia Gamoudi1, Melanie Cutajar2,3, Nadia Gamoudi1

  • 1Department of Medicine Mater Dei Hospital Msida Malta.

Clinical Case Reports
|June 8, 2017
PubMed

In AP syndrome (APS) with severe thrombocytopenia, rituximab represents a unique drug which can balance the effect of bleeding and thrombosis. By reducing the production of autoantibodies, rituximab can simultaneously raise the platelets and reduce the chance of thrombosis by suppressing APL antibodies. Rituximab can supersede splenectomy as second-line therapy in similar patients.

Keywords:
Anticoagulationantiphospholipid syndromerituximabthrombocytopeniathrombosis

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