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Updated: Mar 1, 2026
12:46
Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
Published on: August 17, 2022
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Diffuse large B-cell lymphoma mimicking cardiac amyloidosis
Lawrence Lau1, Viktoriya Mozolevska1, Iain D C Kirkpatrick2
1Section of Cardiology Department of Internal Medicine University of Manitoba Winnipeg Manitoba Canada.
Clinical Case Reports
|June 8, 2017
Summary
Cardiac lymphoma can mimic cardiac amyloidosis on MRI, posing diagnostic challenges. Early detection and chemotherapy are crucial for improved survival rates in these rare cases.
Area of Science:
- Cardiology
- Oncology
- Hematology
Background:
- Cardiac lymphoma is a rare malignancy with diverse clinical presentations.
- Waldenström's macroglobulinemia is a lymphoplasmacytic lymphoma that can transform into more aggressive forms.
- Cardiac involvement in Waldenström's macroglobulinemia is uncommon but can significantly impact prognosis.
Purpose of the Study:
- To highlight a challenging case of cardiac lymphoma mimicking amyloid infiltration.
- To emphasize the importance of considering cardiac lymphoma in the differential diagnosis of myocardial infiltration.
- To underscore the prognostic significance of early diagnosis and treatment.
Main Methods:
- Case report presentation.
- Review of cardiac magnetic resonance (CMR) imaging findings.
- Discussion of diagnostic challenges and treatment implications.
Main Results:
- Cardiac lymphoma presented as diffuse myocardial infiltration, mimicking amyloidosis on CMR.
- The patient had a history of transformed Waldenström's macroglobulinemia, complicating the diagnosis.
- Prompt chemotherapy initiation was associated with improved survival.
Conclusions:
- Cardiac lymphoma can be mistaken for amyloidosis on CMR, necessitating a high index of suspicion.
- Diagnosis is particularly challenging in patients with transformed lymphoproliferative disorders.
- Early recognition and treatment of cardiac lymphoma are critical for patient outcomes.
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