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Liddle Syndrome in Association with Aortic Dissection.

Aamer Abbass1, Jason D'Souza2, Sameen Khalid1

  • 1Internal Medicine Residency, Florida Hospital-Orlando.

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Summary

Liddle syndrome, a rare genetic hypertension, can cause severe end-organ damage. This case highlights a previously unreported association between Liddle syndrome and dissecting aortic aneurysm, emphasizing the need for early diagnosis and management.

Keywords:
aortic dissectionliddle syndromepremature hypertension

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Area of Science:

  • Nephrology
  • Cardiology
  • Genetics

Background:

  • Liddle syndrome is a rare autosomal dominant monogenic hypertension.
  • It presents with early-onset, treatment-resistant hypertension.
  • Delayed diagnosis can lead to severe end-organ damage.

Observation:

  • A patient with Liddle syndrome developed a dissecting aortic aneurysm.
  • This cardiovascular complication has not been previously reported in association with Liddle syndrome.

Findings:

  • The case demonstrates a novel association between Liddle syndrome and aortic dissection.
  • This suggests a potential link between the genetic defect in Liddle syndrome and aortic pathology.

Implications:

  • Early diagnosis and management of Liddle syndrome are crucial to prevent severe complications.
  • This finding may prompt further research into the cardiovascular risks associated with Liddle syndrome.
  • Clinicians should consider aortic complications in patients with Liddle syndrome.