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Updated: Mar 1, 2026
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Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
Published on: May 17, 2019
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Radiation-Induced Oral Mucositis
Osama Muhammad Maria1,2,3, Nicoletta Eliopoulos3,4, Thierry Muanza1,2,3,5
1Faculty of Medicine, Experimental Medicine Department, McGill University, Montreal, QC, Canada.
Frontiers in Oncology
|June 8, 2017
Summary
Radiation-induced oral mucositis (RIOM) significantly impacts head and neck cancer patients, affecting quality of life and treatment continuity. This review covers RIOM
Area of Science:
- Oncology
- Radiation Oncology
- Cancer Therapy
Background:
- Radiation-induced oral mucositis (RIOM) is a severe side effect of radiotherapy for head and neck cancers.
- RIOM negatively impacts patient quality of life and can interrupt cancer treatment.
- It affects 100% of patients undergoing altered fractionation radiotherapy, posing a significant clinical challenge.
Purpose of the Study:
- To provide a comprehensive overview of radiation-induced oral mucositis.
- To discuss the definition, epidemiology, pathogenesis, and clinical impact of RIOM.
- To cover the diagnosis, prevention, and treatment strategies for RIOM.
Main Methods:
- Literature review of radiation-induced oral mucositis.
- Synthesis of information on RIOM definition, epidemiology, and pathogenesis.
- Compilation of data on RIOM scoring, diagnosis, and management.
Main Results:
- RIOM is a frequent and dose-limiting toxicity in head and neck cancer radiotherapy.
- The condition leads to treatment interruptions, affecting tumor control and patient outcomes.
- Estimated economic cost per patient in the US reaches $17,000.
Conclusions:
- Understanding RIOM's multifaceted impact is crucial for effective patient management.
- Comprehensive strategies for prevention and treatment are essential to mitigate RIOM's adverse effects.
- Further research into RIOM pathogenesis and novel therapeutic interventions is warranted.
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