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Serum endocan levels in patients with cardiac syndrome X
S C Efe1, K Demirci2, S Ozturk3
1Department of Cardiology, Agrı State Hospital, Fırat mahallesi, 00004, Agrı, Turkey. scaganefe@gmail.com.
Insights
Patients with Cardiac Syndrome X (CSX) exhibit elevated serum endocan levels, a marker of endothelial dysfunction. This finding suggests endocan may play a role in CSX pathogenesis and could aid in diagnosis.
Area of Science:
- Cardiology
- Biomarkers
- Endothelial Function
Background:
- Endocan is a novel marker associated with endothelial dysfunction, inflammation, and atherosclerosis.
- The relationship between Cardiac Syndrome X (CSX) and endocan has not been previously investigated.
Purpose of the Study:
- To compare serum endocan levels in patients diagnosed with CSX versus healthy controls.
- To explore the potential of endocan as a diagnostic marker for CSX.
Main Methods:
- A cohort of 50 CSX patients and 28 controls were enrolled.
- Exclusion criteria targeted conditions affecting endothelial function.
- Serum endocan concentrations were quantified using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- CSX patients demonstrated significantly higher mean serum endocan levels compared to controls (3051.3 ± 1900.5 ng/l vs. 2088.1 ± 522.2 ng/l; p=0.002).
- Demographics and cardiovascular risk factors (age, gender, hypertension, diabetes, dyslipidemia, smoking) were comparable between groups.
- Receiver operating characteristic (ROC) analysis indicated endocan levels >2072 ng/l had 72% sensitivity and 54% specificity for CSX diagnosis (p=0.002).
Conclusions:
- Elevated serum endocan levels are associated with CSX.
- Endocan may serve as a valuable biomarker for understanding CSX pathogenesis.
- Further research is warranted to elucidate the role of endocan in CSX.
Background:
Endocan is a recently introduced marker of endothelial dysfunction and is also associated with inflammation and atherosclerosis. To date, the relationship between cardiac syndrome X (CSX) and endocan has not been studied. The objective of this study was to compare the serum endocan levels of patients with CSX with those of control subjects.
Patients And Methods:
In this study, 50 patients were included in the CSX group and 28 patients in the control group. Patients with pathological conditions that could potentially influence endothelial functions were excluded. Endocan serum concentrations were measured using an enzyme-linked immunosorbent assay.
Results:
The mean endocan level of the CSX group was significantly higher than that of the control group (3051.3 ± 1900.5 ng/l vs. 2088.1 ± 522.2 ng/l; p = 0.002). There was no difference between the two groups in terms of age, gender, hypertension, diabetes mellitus, dyslipidemia, and smoking status. In receiver operating characteristic (ROC) curve analysis, endocan levels greater than 2072 ng/l had a 72% sensitivity and 54% specificity (p = 0.002) for accurately predicting a diagnosis of CSX.
Conclusion:
The results of this study suggest that patients with CSX have higher endocan levels. Therefore, endocan may be valuable in helping uncover the underlying pathogenesis of CSX.
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