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Related Concept Videos

Renewal of Intestinal Stem Cells01:23

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Related Experiment Video

Updated: Mar 1, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
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Teduglutide-induced stem cell function in intestinal repair.

Ferenc Sipos1, Györgyi Műzes1

  • 1a 2nd Department of Internal Medicine , Semmelweis University , Budapest , Hungary.

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
|June 8, 2017
PubMed
Summary

Teduglutide enhances intestinal repair by modulating distinct stem cell populations in short bowel syndrome (SBS) and inflammatory bowel diseases (IBD) models. This offers insights into new treatments for malabsorption.

Keywords:
Bmi1Lgr5inflammatory bowel diseasesintestineshort bowel syndromestem cellsteduglutide

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Area of Science:

  • Gastroenterology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Malabsorption is a primary clinical feature of short bowel syndrome (SBS) and inflammatory bowel diseases (IBD).
  • Current treatments focus on reducing malabsorptive losses, but novel therapies aim to enhance intestinal absorptive capacity.
  • Teduglutide, an intestinal growth factor, is a promising therapeutic agent for improving bowel function.

Purpose of the Study:

  • To investigate the role of distinct epithelial stem cell subpopulations in intestinal repair following surgical injury.
  • To analyze the behavior of these stem cells after teduglutide administration in a rat model.
  • To understand the potential implications of growth factor therapy on stem cell modulation and intestinal healing.

Main Methods:

  • Utilized a rat model of ileal resection and anastomosis to study intestinal injury.
  • Identified and characterized two distinct functional putative epithelial stem cell subpopulations: Lgr5+/Bmi1- and Lgr5-/Bmi1+.
  • Assessed the behavior of these stem cell subpopulations in response to surgical injury and teduglutide treatment.

Main Results:

  • Two distinct epithelial stem cell subpopulations (Lgr5+/Bmi1- and Lgr5-/Bmi1+) were identified in the rat model.
  • These subpopulations exhibited differential responses to surgical injury and teduglutide administration.
  • Teduglutide demonstrated clinical effectiveness, but potential risks of adenoma development warrant consideration.

Conclusions:

  • Stem cell modulation plays a crucial role in intestinal repair after injury.
  • Understanding stem cell behavior provides insights into the efficacy of teduglutide.
  • Results pave the way for developing new perioperative adjuvant therapies for SBS and IBD to mitigate malabsorption complications.