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Updated: Mar 1, 2026
Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
Expression of KGF-1 and KGF-2 in Skin Wounds and Its Application in Forensic Pathology
Lin Sheng Yu1, Xing Biao Li, Yan Yan Fan
1From the *Department of Forensic Medicine, †Forensic Center, and ‡Institute of Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang Province, China; §Forensic Medical Management Services, Nashville, TN; and ∥Shanghai Key Lab of Forensic Medicine, Shanghai City West, Shanghai, China.
Abstract:
The expression of keratinocyte growth factor-1 (KGF-1) and keratinocyte growth factor-2 (KGF-2) in skin wounds in mice was studied using multiple methods. The dynamic expression of KGF-1 and KGF-2 for antemortem and postmortem injuries as well as the examination of antemortem injuries after death under different temperature and over varying time periods was studied. It demonstrates that skin KGF-1 resulting from an antemortem injury starts to rise at 6 hours, reaches its peak at 1 day, and starts to drop at 5 days. The expression of skin KGF-2 resulting from an antemortem injury starts to rise at 12 hours, reaches its peak at 7 days, and begins to drop at 10 days. Skin KGF-1 and skin KGF-2 after death stabilize within 7 days at 4°C and -20°C, within 5 days at 20°C, and within 1 day at 30°C. The application of KGF-1 and KGF-2 indicators in skin wound age determination is both feasible and reliable.
