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Updated: Mar 1, 2026

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Epstein-Barr Virus-Positive Mucocutaneous Ulcer Mimicking Rectal Carcinoma at 18F-FDG PET/CT
Anna Margherita Maffione1, Lucia Rampin, Rossella Paolini
1From the Departments of *Nuclear Medicine and PET, †Hematology, ‡Pathology, and §Radiation Oncology, Santa Maria della Misericordia Hospital, Rovigo, Italy; and ∥Department of Radiology, University of Southern California, Los Angeles, CA.
Abstract:
We report focally intense F-FDG PET/CT rectal activity (SUVmax = 25) with a horseshoe distribution in an 81-year-old man with B-cell chronic lymphocytic leukemia and suspected Richter transformation. While imaging findings were typical for rectal adenocarcinoma, histology revealed Epstein-Barr virus-positive mucocutaneous ulcer.
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